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M94A3007.TXT
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1994-10-25
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Document 3007
DOCN M94A3007
TI EBV type A and B association with primary CNS lymphomas.
DT 9412
AU Ciardi M; Del Re V; Toma L; Fedele CG; Cirelli A; Sorice F; Dept.
Infectious Diseases, La Sapienza University, Rome, Italy.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):175 (abstract no. PB0125). Unique
Identifier : AIDSLINE ICA10/94369568
AB OBJECTIVE: Epstein-Barr virus (EBV) is often associated with HIV
infection and seems to play a pathogenic role on AIDS-related primary
lymphomas of the central nervous system (CNS); in fact EBV virus has
been detected in both brain tissue by in situ hybriditation and
cerebrospinal fluid (CSF) by polymerase chain reaction (PCR) in HIV
patients affected by primary CNS limphoma. It has been shown that there
are two EBV strains, type A and B, but until now neither type seems to
have a specific disease association. METHODS: We performed PCR to detect
type A and B EBV-DNA using different sets of specific primers on CSFs of
five AIDS patients with primary CNS lymphoma. We tested previously these
CSFs for EBV-DNA by a nested PCR using other primers. RESULTS: All 5
patients affected by primary CNS lymphoma were positive for EBV-DNA;
four out of 5 showed positivity for type A EBV-DNA and 1 for type B.
DISCUSSION AND CONCLUSIONS: We noted a high prevalence of type A EBV-DNA
in primary CNS limphomas; that could be due to geographical distribution
but we think that there is a possibility that type A EBV could be more
strictly associated with primary CNS limphomas than type B. Further
studies will be required to establish if there is a difference of
prevalence between type A and B EBV in other lymphoproliferative
diseases in HIV patients.
DE Brain/MICROBIOLOGY Brain Neoplasms/*MICROBIOLOGY DNA, Viral/*GENETICS
Herpesvirus 4, Human/CLASSIFICATION/*GENETICS Human Lymphoma,
AIDS-Related/*MICROBIOLOGY Polymerase Chain Reaction/METHODS Tumor
Virus Infections/*MICROBIOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).